), and it is well absorbed. • Cyclophosphamide Contraindications The drug shouldn't be used in dogs with: Bone marrow problems or a low white and red blood cell count Sensitivity to cyclophosphamide Severe infections (which need to be treated prior to starting the cure with cyclophosphamide) Kidney issues Advanced liver damage Cyclophosphamide Dosage The chemical name for cyclophosphamide is 2-[bis(2-chloroethyl)amino]tetrahydro-2H-1,3,2-oxazaphosphorine 2-oxide monohydrate. Cyclophosphamide; 2. Who might be offered EC chemotherapy? Cyclophosphamide in combination with glucocorticoid (steroids) is the mainstay of treatment in most cases. Cyclophosphamide. Overview of Cyclophosphamide Medications Available in Spain and in the . You . CONTRAINDICATIONS Cyclophosphamide is contraindicated in: Patients who have demonstrated hypersensitivity to this drug or its metabolites, alone or as part of combination chemotherapy Patients with urinary outflow obstructions Patients with severe myelosuppression Patients with severe renal impairment Patients with severe hepatic impairment Patients with an active infection, particularly . You will get fluids and a medication called mesna through your IV line. 6.1 Serious; 6.2 Common; 7 Pharmacology; 8 Mechanism of Action; 9 Comments; 10 See Also; 11 References; Administration. Pharmacodynamics. Cyclophosphamide is commonly administered intravenously but it is also available as an oral agent, although this is . Examples include organ-threatening manifestations of rheumatic diseases such as systemic lupus erythematosus (SLE), granulomatosis with polyangiitis (GPA), microscopic . The only absolute contraindications are pregnancy and lactation. The patient has already received a total of 2.4g of cyclophosphamide (4 cycles of 600mg each every three weeks). Type: Prescribing and Technical Information (Add filter) Add this result to my export selection. YES/NO Counselled by: Patient given PIL? Cyclophosphamide is an alkylating drug indicated for treatment of: . FSGS of undetermined cause (FSGS-UC) was added to differentiate those . In What Dosage Forms is Cyclophosphamide Currently Marketed? metabolism . Acrolein and phosphoramide are the active compounds, and they slow the growth of cancer cells by interfering with the actions of deoxyribonucleic acid (DNA) within the cancerous cells. View fullsize. Hair loss; Nausea and vomiting; Decreased appetite; Nail damage including darkening of the nails; Changes in menstrual period; Serious Side Effects . Try to urinate (pee) every 2 hours during your treatment. 15 Diuretics, angiotensin-converting enzyme inhibitors, and β-blockers should be instituted early if there are no contraindications. Used in the treatment of cancer., . Anaphylactic reactions including death have been reported with cyclophosphamide. You can have cyclophosphamide on its own, or in combination with other chemotherapy drugs. In patients with urinary outflow . • Manifest Scalp metastases • Imminent bone marrow ablation chemotherapy • Imminent skull irradiation (Paxman 2016 . Chapter 6: Focal Segmental Glomerulosclerosis (FSGS) in adults. Cyclophosphamide is contraindicated in patients who have demonstrated a previous hypersensitivity to it. Possible cross-sensitivity with other alkylating agents can occur. CONTRAINDICATIONS Continued use of cyclophosphamide is contraindicated in patients with severely depressed bone marrow function. The coating of the cyclophosphamide tablets prevents direct contact of persons handling the tablets with the active substance. • acute infections, • bone-marrow aplasia, Cyt P450 metabolism produces 4-hydroxycyclophosphamide (an active metabolite) which . 4.3 Contraindications Cyclophosphamide is contra-indicated in patients with: • hypersensitivity to cyclophosphamide or to any of its metabolites. -----CONTRAINDICATIONS----- Hypersensitivity to cyclophosphamide (4) Urinary outflow obstruction (4) Urinary Tract and Renal Toxicity - Hemorrhagic cystitis, pyelitis, ureteritis, and hematuria can occur. Cyclophosphamide is indicated in: Severe systemic rheumatoid arthritis and other connective tissue disorders, especially with vasculitis. (See WARN-INGS and PRECAUTIONS.) Cyclophosphamide is a white crystalline powder with the molecular formula C7H15CI2N2O2P•H2O and a molecular weight of 279.1. Cyclophosphamide is an alkylating agent of the nitrogen mustard type. Cyclophosphamide is contraindicated in patients with: • hypersensitivity to cyclophosphamide, any of its metabolites • acute infections • bone marrow aplasia or bone marrow depression prior to treatment • urinary tract infection • acute urothelial toxicity from cytotoxic chemotherapy or radiation therapy • urinary outflow • obstruction • breastfeeding . Indication It is used to treat the most severe presentations or flares of connective tissues diseases and systemic vasculitis such as juvenile systemic lupus erythematous, juvenile . Type: Antineoplastic/immune modulating agent ; Dosage Forms: Routes of Administration: IV, oral; Common Trade Names: Adult Dosing. Dosage Forms Marketed in The 1.2.3. Before taking . the product. Discontinue cyclophosphamide therapy if the neutrophil count decreases to <2 × 109/l; check count weekly and do not resume . Common adverse side effects reported in several studies and clinical trials involving the use of cyclophosphamide include hemorrhagic cystitis, amenorrhea, myelosuppression, alopecia, and spells of nausea and vomiting. 250 mg/m2/day IV on days 1 to 3 in combination with fludarabine 25 mg/m2/day IV on days 1 to 3 repeated every 28 days for up . Severe uncontrolled cardiac disease. Cyclophosphamide Sugar-coated Tablets . These actions do not appear to be cell-cycle specific. Conception and contraception Manufacturer advises effective contraception during and for at least 3 months after treatment in men or women. Contraindications : Continued use of cyclophosphamide is contraindicated in patients with severely depressed bone marrow function. Special Precautions . Vasculitis: 2 mg/kg PO daily OR 15mg/kg IV q2 weeks x3 then q3 weeks. Cyclophosphamide is a drug that is used primarily for treating several types of cancer.In order to work, cyclophosphamide first is converted by the liver into two chemicals, acrolein and phosphoramide. Vincristine is a vesicant, therefore catheters should be placed in all cases and only catheters placed by 'first-stick' should be used. CYCLOPHOSPHAMIDE Tablets USP 25 mg and 50 mg DESCRIPTION Cyclophosphamide is a synthetic antineoplastic drug chemically related to the nitrogen mustards. Anaphylactic reactions including death have been reported with cyclophosphamide. Patient w/ bone marrow aplasia, urinary outflow obstruction, UTI, acute infection, drug- or radiation-induced urothelial toxicity. Cross-sensitivity . Contraindications for Rituximab: Pregnancy, lactation, Previous TB (unless treated), hypersensitivity. It suppresses the body's immune response and reduces inflammation in your lungs. Cyclophosphamide is contraindicated in patients who have a history of severe hypersensitivity reactions to it, any of its metabolites, or to other components of the product. IUPAC name (RS)-N,N-bis(2-chloroethyl)-1,3,2-oxazaphosphinan-2-amine 2-oxideRS)-N,N-bis(2-chloroethyl)-1,3,2-oxazaphosphinan-2-amine 2-oxide Contraindications and adverse effects Myelosuppression, haemorrhagic cystitis (cyclophosphamide only) or GI effects may occur. CYCLOPHOSPHAMIDE / BORTEZOMIB / DEXAMETHASONE (VCD) INDICATIONS 1- First-line treatment of multiple myeloma in patients who are unable to tolerate, or have contraindications to, thalidomide and who are unsuitable for stem cell transplantation [NICE TA228] 2- Induction treatment of adult patients with previously untreated MM who are eligible for high dose chemotherapy with hematopoietic stem . EC chemotherapy may be given before surgery, known as neo-adjuvant . Cyclophosphamide is an antineoplastic in the class of alkylating agents and is used to treat various forms of cancer. Pregnancy Cyclophosphamide is an alkylating drug indicated for treatment of: . with other alkylating agents can occur. Contraindications: Pregnancy, lactation, hypersensitivity haemorrhagic cystitis and porphyria Patient counselled? (5.2) Cardiotoxicity - Myocarditis . Cyclophosphamide works by damaging the DNA of cancer cells. This updated Medicines Q&A is a quick reference summary to different types of enteral feeding tubes, in relation to medication issues. Cross-sensitivity with other alkylating agents can occur . Anaphylactic reactions including death have been reported with cyclophosphamide. Patient w/ DM, severe immunosuppression, acute porphyria, pre-existing CV disease or . Primary care monitoring requirements for people on cyclophosphamide. Cautions. Cyclophosphamide Injection is contraindicated in patients who have a history of severe hypersensitivity reactions to it, any of its metabolites, or to other components of the product. It is a treatment for a number of different types of cancer. WebMD provides common contraindications for cyclophosphamide intravenous. The main areas of concern regarding the adverse side effects of cyclophosphamide are associated with bladder and gonadal toxicity. Because inflammation is the precursor to fibrosis (scarring), we hope cyclophosphamide will prevent the formation of lung fibrosis and allow the inflamed lung to return to normal. Methods of Administration and Dosages 9 1.2. Skin binding improved significantly in 90% of our patients although Raynauds . Cyclophosphamide is a synthetic antineoplastic drug chemically related to the nitrogen mustards. Pregnancy. Data from: [Yorkshire Rheumatology Regional Guidelines for . It was possible to induce remission in majority of our patients with PSS. cyclophosphamide (CPM) pulse therapy in a group of 75 patients suffering from various autoimmune disorders (mostly systemic lupus erythematosus and vasculitis) who received a total of 451 i.v. Cyclophosphamide is also used for retinoblastoma (a type of eye cancer mainly in children), multiple myeloma (cancer in the bone marrow), and mycosis fungoides (tumors on the skin). cyclophosphamide: [ si″klo-fos´fah-mīd ] a cytotoxic alkylating agent , one of the nitrogen mustards , used in antineoplastic therapy for a wide variety of conditions, often in combination with other agents; also used as an immunosuppressant to prevent transplant rejection and in the treatment of certain diseases with abnormal immune function. Intravenous dosage. The 3 most frequently used platforms consist of (1) posttransplant cyclophosphamide (PTCy); (2) granulocyte colony-stimulating factor priming, intensive postgrafting immunosuppression, and antithymocyte globulin using combined peripheral blood stem cell and bone marrow (BM) allografts; and (3) T-cell depletion with either "megadose" CD34 + cells or selected α/β T-cell and B-cell depletion. Cyclophosphamide is a nitrogen mustard that exerts its anti-neoplastic effects through alkylation. 4 CONTRAINDICATIONS . Improve clinical decision support with information on contraindications & blackbox warnings, population restrictions, harmful risks, & more. 2. An activated form of cyclophosphamide, phosphoramide mustard, alkylates, or binds, to DNA. Steroid sparing agents like MMF, CNI, cyclophosphamide and rituximab can be used in those with contraindications to steroids or frequently relapsing nephrotic syndrome. Page 1 of 6 Produced by Nick Wilkinson, Rhoda Welsh, Eunice Kendall and Emma Inness based on protocol of Connie . Contraindications for Cyclophosphamide: Pregnancy, lactation, hypersensitivity, haemorrhagic cystitis and porphyria. Life threatening . Exclude or correct any urinary tract obstructions prior to treatment. The fluids and mesna will help protect your bladder during your treatment. Possible cross-sensitivity with other alkylating agents can occur. 5 Contraindications; 6 Adverse Reactions. The Committee noted the . What special precautions should I follow? During your cyclophosphamide treatment, you will have an intravenous (IV) line. Medscape - Indication-specific dosing for Cytoxan (cyclophosphamide), frequency-based adverse effects, comprehensive interactions, contraindications, pregnancy & lactation schedules, and cost information. [BNF 73, 2017] It has been used extensively to treat severe manifestations of a variety of autoimmune and inflammatory diseases. Alkylating . AB - Seventy-one patients received adjuvant Cytoxan (cyclophosphamide; Bristol-Myers Co, Evansville, IN), Adriamycin (doxorubicin; Adria Laboratories, Columbus, OH), and cisplatin (CISCA) chemotherapy between March 1981 and March 1986. Contraindications: patients with severely depressed bone marrow function. Find out what health conditions may be a health risk when taken with cyclophosphamide intravenous Active severe infections. British National Formulary for Children - BNFc (Add filter) 16 September 2021. PHARMACOKINETICS: Interpatient variability . If the disease is . Cyclophosphamide has an important role as an antineoplastic medicine, however these indications are outwith the scope of this topic. Avoid life-threatening adverse drug events & improve clinical decision support. Once diagnosed, the treatment of cyclophosphamide-induced heart failure and arrhythmias should be no different from the general approach. 5 Contraindications; 6 Adverse Reactions. • Urinary Outflow . Cyclophosphamide is contraindicated in patients who have demonstrated a previous hypersensitivity to it. Liver Function Tests (LFTs): ALT and/or AST* and albumin: Urinalysis *AST, aspartate transaminase; ALT, alanine aminotransferase. Monumental success of dexamethasone-cyclophosphamide pulse (DCP) . Its cytotoxic effect is mainly due to cross-linking of strands of DNA and RNA, and to inhibition of protein synthesis. WARNINGS Carcinogenesis, Mutagenesis, and Impairment of Fertility Second malignancies have developed in some patients treated with . Primary breast cancer. Drug Interactions Cyclophosphamide is often used in combination with other cytotoxic drugs or immunosuppressant agents thus additive toxicity is likely to occur. Learn more. Cyclophosphamide is used to treat various types of cancer.It is a chemotherapy drug that works by slowing or stopping cell growth.Cyclophosphamide also works by decreasing your immune system's . Exclude or correct any urinary tract obstructions prior to treatment. Mild to moderate heart failure and small pericardial effusions generally resolve within a few days to weeks after . A new classification system is proposed by these guidelines. PREPARE: Direct: Add 5 mL sterile water for injection or bacteriostatic water for injection (paraben-preserved only) to each 100 mg and shake gently to dissolve. Relative contraindications are severe hypertension, stroke, myocardial infarction, peptic perforation, etc. Like other alkylating agents, cyclophosphamide is teratogenic and contraindicated in pregnant women ( pregnancy category D) except for life-threatening circumstances in the mother. Cyclophosphamide is indicated in: Severe systemic rheumatoid arthritis and other connective tissue disorders, especially with vasculitis. For both men and women: Use contraceptives, and do not conceive a child (get pregnant) while taking cyclophosphamide. Urinary Outflow Obstruction Cyclophosphamide in its parent form does not have direct cytotoxic effects. Urinate before you go to bed. Cyclophosphamide Tablets are contraindicated in patients with: • A history of severe hypersensitivity reactions to Cyclophosphamide, any of its metabolites, or to other components of the product. Cross-sensitivity with other alkylating agents can occur . DO NOT take this medication if you are allergic to cyclophosphamide products or if you have a low white blood cell count. CONTRAINDICATIONS Cyclophosphamide Tablets are contraindicated in patients with: • A history of severe hypersensitivity reactions to cyclophosphamide, any of its metabolites, or to other components of the product. For full details on contraindications, consult product literature. See WARNINGS and PRECAUTIONS. Women who are pregnant or become pregnant must be advised of the potential hazard to the fetus. Chemotherapy is given to reduce the risk of breast cancer returning or spreading. For patients in reproductive ages and for other situations where there are contraindications to the use of cyclophosphamide, your doctor may choose to use rituximab. Anaphylactic reactions including death have been reported with cyclophosphamide. [BNF 73, 2017] Cyclophosphamide may be hazardous to the fetus. Pulmonary and radiological regression, as well as improvement of renal parameters have been achieved. Common Side Effects. It belongs to the group of cancer medicines called alkylating agents. The DNA . Contraindications Cyclophosphamide Good clinical response? The Committee was also aware that transplant rates for the comparison of bortezomib and dexamethasone (without thalidomide) against cyclophosphamide, thalidomide and dexamethasone, were incorporated from the IFM trial for the bortezomib and dexamethasone arm (89.1%) and from the MRC Myeloma IX trial for the cyclophosphamide, thalidomide and dexamethasone arm (66.7%). Stability information is essential for the safe aseptic preparation of cyclophosphamide Following the review of stability for cytotoxic drugs for the NHS tender, these monographs are designed to capture the information in a format that is useful for NHS aseptic units, particularly those working under Section 10 exemption with restricted shelf lives for products. Contraindications. Bone marrow suppression including Decrease in the number of circulating white blood . YES/NO . CPM pulses, given on a monthly basis (mean +/- s.d. (5.2) Cardiotoxicity - Myocarditis . Adverse effects, precautions and contraindications Contraindicated in: pregnancy, patients with known hypersensitivity to cyclophosphamide, with acute infections, with bone-marrow aplasia, urinary tract infection or with acute urothelial toxicity from cytotoxic chemotherapy or radiation therapy. Dosage Forms Marketed in Spain 10 1.2.2. In specific circumstances, methotrexate or mycophenolate mofetil may be substituted for cyclophosphamide. Cyclophosphamide is used to treat cancer of the ovaries, breast, blood and lymph system, and nerves (mainly in children). -----CONTRAINDICATIONS----- Hypersensitivity to cyclophosphamide (4) Urinary outflow obstruction (4) Urinary Tract and Renal Toxicity - Hemorrhagic cystitis, pyelitis, ureteritis, and hematuria can occur. Patients received adjuvant CISCA chemotherapy if they had pathological findings that were thought to predict for high likelihood of relapse. Anaphylactic reactions including death have been reported with cyclophosphamide. CONTRAINDICATIONS Cyclophosphamide Tablets are contraindicated in patients with: • A history of severe hypersensitivity reactions to cyclophosphamide, any of its metabolites, or to other components of the product. 3. As with all cytotoxic therapy, treatment with cyclophosphamide is associated with an increased incidence of secondary malignancies. INTRAVENOUS CYCLOPHOSPHAMIDE Therapeutic class: Precursor of an alkylating nitrogen mustard antineoplastic and immunosuppressive agent that must be activated in the liver to form the active aldophosphamide. The tablets are coated and should not be divided before use. Adults. 6.1 Serious; 6.2 Common; 7 Pharmacology; 8 Mechanism of Action; 9 Comments; 10 See Also; 11 References; Administration. United States of America 10 1.2.4. CONTRAINDICATIONS Continued use of cyclophosphamide is contraindicated in patients with severely depressed bone marrow function. Personnel should avoid exposure to broken tablets. See also Pregnancy and reproductive function in Cytotoxic drugs. Cyclophosphamide is used to treat various types of cancer.It is a chemotherapy drug that works by slowing or stopping cell growth.. Cyclophosphamide also works by decreasing your immune system's response to various diseases. Cyclophosphamide (CTX) is an antineoplastic alkylating agent used to treat a wide variety of malignant and non-malignant disorders (Frasier, Kanekal, & Kehrer, 1991). Cross-sensitivity with other alkylating agents can occur. • In patients with urinary outflow . 4 CONTRAINDICATIONS • Hypersensitivity. Vasculitis: 2 mg/kg PO daily OR 15mg/kg IV q2 weeks x3 then q3 weeks. History of cardiovascular disease (exacerbation of angina, arrhythmia, and heart failure have been reported) ; patients receiving cardiotoxic chemotherapy (exacerbation of angina, arrhythmia, and heart failure have been reported); pre-medication recommended to minimise adverse reactions (consult product literature . Adjust dose to avoid severe . Conclusions: We suspect that cyclophosphamide, the drug of choice in p-ANCA vasculitis, could be a potential factor providing regression of the radiological changes in the lungs and . Cyclophosphamide Capsules are contraindicated in patients with: A history of severe hypersensitivity reactions to cyclosphosphamide, any of its metabolites, or to other components of . Paediatric Rheumatology Cyclophosphamide Protocol Nuffield Orthopaedic Centre and Children's Hospital, Oxford Page 3 of 9 Produced by Nick Wilkinson and Rhoda Welsh, based on protocol of Connie Kon and Raashid Luqmani, Nuffield . Additional relative contraindications to the use of cyclophosphamide include lactation, active infection, neutropenia or bladder toxicity. Cyclophosphamide (CYC), an alkylating agent, is one of the most potent immunosuppressive therapies available. Cyclophosphamide is a white crystalline powder with the molecular formula C7H15Cl2N2O2P• H 2O and a molecular weight of 279.1. CPM dose per pulse: 764 +/- 217 mg; mean +/- s.d. 4.3 Contraindications. For the first-line treatment of CLL, in combination with fludarabine. Dosing : Libido and sexual capability are usually not affected. Pharmacokinetics: Can be given orally (most alkylating agents are given i.v. After your treatment, try to urinate every 3 to 4 hours while you're awake. This is breast cancer that has not spread beyond the breast or lymph nodes (glands) under the arm. Blood tests repeated immediately prior to the next pulse. Contraindications to Scalp Cooling . follow-up period: 26.7 +/- 22.1 mon). You should not breastfeed while taking cyclophosphamide, and you should use barrier contraception to prevent pregnancy. • Cyclophosphamide • Daunorubicin • Docetaxel • Doxorubicin • Epirubicin • Paclitaxel . Contraindications . Adjust dose to avoid severe . • In patients with urinary outflow . Monitoring Frequency; Full Blood Count (FBC) 10 days after each pulse therapy. NOTE: Cyclophosphamide is approved for the treatment of CLL; however, all components of combination regimens may not have been evaluated by the FDA for the treatment of CLL. Cyclophosphamide Injection: 200 mg per mL (500 mg per 2.5 mL, 1 gram per 5 mL and 2 grams per 10 mL) in a multiple-dose vial (3) CONTRAINDICATIONS Hypersensitivity to cyclophosphamide (4) Urinary outflow obstruction (4) WARNINGS AND PRECAUTIONS Myelosuppression, Immunosuppression, Bone Marrow Failure and Infections - Severe immunosuppression may lead to serious and sometimes fatal infections . The chemical name for cyclophosphamide is 2 H-1,3,2-Oxazaphosphorin-2-amine, N,N-bis(2-chloroethyl) tetrahydro . Cyclophosphamide is . Cyclophosphamide may cause temporary or permanent sterility in women and in men, depending upon the dose and duration of therapy. It is used to treat a certain type of kidney disease in children after other treatments have not worked.. Cyclophosphamide may also be used for various conditions such as . Cyclophosphamide (pronounced sigh-clo-fos-fah-mide) is a type of chemotherapy. Not all enteral feeding… Avoid in patients with cystitis from any cause until it has been treated. Cyclophosphamide is contraindicated in patients who have demonstrated a previous hypersensitivity to it. 10 1.2.1. Cyclophosphamide is used alone or in combination with other medications to treat Hodgkin's lymphoma (Hodgkin's disease) and non-Hodgkin's lymphoma (types of cancer that begin in a type of white blood cells that normally fights infection); cutaneous T-cell lymphoma (CTCL, a group of cancers of the immune system that first appear as skin rashes); multiple myeloma (a type of cancer of the bone . GUIDELINES FOR USE OF INTRAVENOUS ILOPROST Trust . EC chemotherapy can be used to treat primary breast cancer. Cyclophosphamide Tablets should be swallowed with sufficient fluid without chewing. Type: Antineoplastic/immune modulating agent ; Dosage Forms: Routes of Administration: IV, oral; Common Trade Names: Adult Dosing. Side effects and contraindications In the short term, side effects can include hair loss, nausea, infertility, bladder irritation, gum soreness and risk of infection. Store cyclophosphamide PO solution in refrigerator at 2°-8° C (36°-46° F), and use within 14 d. Intravenous. Anaphylactic reactions including death have been reported with Cyclophosphamide. Indications, dose, contra-indications, side-effects, interactions, cautions, warnings and other safety information for CYCLOPHOSPHAMIDE. Cyclophosphamide is part of a class of drugs called immunosuppressants. This activity reviews the indications, contraindications, mechanism of action, and other key factors of cyclophosphamide as a valuable agent in the treatment and management of neoplastic diseases by an interprofessional team. View fullsize. However, to prevent inadvertent exposure to the active substance, the cyclophosphamide tablets should not be cut, chewed, or crushed. In stock alternatives of Cyclophosphamide (based on Cyclophosphamide ) Endoxan Tablet - ₹42.42 Endoxan Asta 200 Injection - ₹45.35 Endoxan Asta 1000 Injection - ₹158.7 Endoxan Asta 500 Injection - ₹50.54 We reviewed the side-effects of intravenous (i.v.) Scalp cooling is contra-indicated in: • Patients with a haematological malignancy • Cold sensitivity • Cold agglutinins disease. 1.1.3. Adverse Effects and Contraindications 9 1.1.4. It is used in pediatric oncology as part of the standard treatment for leukemia, solid tumors and brain tumors. Learn more. WARNINGS Carcinogenesis, Mutagenesis, Impairment of Fertility: Second malignancies have developed in some patients treated with . Cyclophosphamide has an important role as an antineoplastic medicine, however these indications are outwith the scope of this topic. It must be bioactivated by cyt P450 to be effective. No Yes, continue CYC Further CYC infusions X3 3 weekly X 3 (Weeks 7, 10, 13) Rituximab Further CYC infusions X 4 3 weekly X 3 (Weeks 17, 20, 23) Algorithm for treatment of primary systemic vasculitis Remission Yes, continue CYC No, continue if disease refractory or consider RITUXIMAB . Cyclophosphamide: Belongs to the class of alkylating agents, nitrogen mustard analogues. How cyclophosphamide works. An antiemetic medication may be prescribed to be given before the drug. These included the .
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