He was a normal dog before the medicine Simpatico Trio . And urinating more often as a result. Simparica uses Sarolaner, which works by overstimulating the nervous system of the pests. I gave our boy, Yogi his first dose of Simparica TRIO on 11/17/2020. Thank you in advance. My dog is still having tremors 5 months after taking Simparica. I have been telling everyone not to give this to their furry ones!!!!!!!! She is lethargic, unsteady on her feet, doesnt bark at all, showing signs of dimentia. The innovative formula disrupts gamma-aminobutyric acid (GABA) and glutamate receptors, which both play a role in nerve transmissions. The vet came and picked her up and cut her opened and said and told me she could anything wrong with her so it was either she was poisoned or it was a neurological disorder. My dog was super sick the first months of his life. I am so worried after reading these comments. Simparica Trio should be used with caution in dogs with a history of seizures. How is your dog now? I'm hoping the tremors will soon diminish, since she is in great shape otherwise. The Simparica was recommended by the vet. No more of this med! For the vast majority of . Vet suggested that I switch to Simparica Trio (he gets a kickback from the manufacturer). He is eating fine with no diarrhea or vomiting. Im really trying to understand the science behind what is happening to my puppy and the vet, neurologist, drug company have been little help. We will reimburse you up to $30.00 for an alternative approved flea treatment or reimburse you the cost of one dose . Thank you all for speaking out on Simparica Trio that Bandfield Hospital pushed on our Toy Poodle. I am taking them both off Simparica. The only change I could think of he started taking Simparica about 4 months ago. Side-Effects Of Simparica Trio Tablets There are some mild side effects like Vomiting Diarrhea Loss of appetite Dog owners should be aware that these tablets are not suitable for all dogs. Update on my Labradoodle who started seizures just a few hours after receiving first dose of Simparica on T-Day 2020 it is March 2021 and my Vet put my dog on Phenobarbital for anti-seizure med. have been seen after using medications in this class of drugs. This medication is given once a month by mouth, with or without food. Side effects are rare and may include: Neurologic side effects have been seen after using medications in this class of drugs. Some had fleas, some had heartworms, and some had roundworms. Use with caution in dogs with a history of seizures or neurologic disorders. No appetite, not like Charlie. Soft stools. She was shaking like she was freezing. I am so sad to read what is happening to some pets. Im going to another vet and discontinuing simparica. Topical only for me from now on. Will not use this again and will warn others. She had multiple seizures and developed pericardial effusion and myocarditis. She also started with ear infections. He has all the symptoms Eveyone is describing. My other two dogs had a little loose stool but nothing else. All the swelling went down immediately and the itching went away too. My 3 month old shih tux Juno took her second dose last week and for the last two days shes vomited and has been eating grass nonstop! As I said, the first was a week after taking it, then the 2nd and third seizure happened at day 29. The king cavalier bichon mix seems to be ok just not eating much if at all. Called his vet and they gave no information. Mine is due for another dose next week and I don't know what to do. Our two shih tzus are 6.5. Good bless you all. Same here! She has NEVER done that before. After 9 days he began vomitting, even water, and mouth chattering like he was scared. I am trying to remain confident that my poor girl will recover. Getting him to go out was nearly impossible. Simparica Trio contains sarolaner, a member of the isoxazoline class, which has been associated with neurologic adverse reactions including tremors, ataxia, and seizures in dogs with or without a history of neurologic disorders. Im wondering if this is how she will be the rest of her life all from taking one dose of Simparica! but wasnt allowed in with him. How is your dog doing? It is Now 3 pm and Lily is on her way to the animal hospital and most likely going to have to spend the night, we will flush her with iv and hope It helps Flush It out Of her system. Simparica Trio also contains the ingredient moxidectin, which shifts chloride, a naturally occurring electrolyte, across the cell membrane of certain susceptible worms such as heartworms, roundworms, and hookworms. Hi, we did a spinal tap and MRI, its not viral or bacterial, its called steroid responsive meningitis which essentially is the meninges inflaming on their own, but if you look in this thread youll see others reporting similar symptoms/diagnosis so I do think Simparica trio triggered/caused it. Pyrantel Pamoate was first approved in 1977 for the treatment and . Now her dog is very sick and she has to take the dog to the vet every day in the past week. Stay safe! My dog was HEALTHY and HAPPY prior to giving him this drug and literally days later he is struggling to recover. He's a 1 1/2 y.o. Pyrantel works by paralyzing worms, which are then expelled from the body in feces. By the evening she lost the use of her hind legs. After her first dose she had diarrhea, vomiting and developed a terrible wheezing hacking cough. Very small sample - many deformities, stillborn. In our case the damage was permanent. He seemed okay with his next dose January 1, so we renewed the prescription, and I gave him the February dose too. Just hoping you can give me something good and tell me your dog recovered. Use topical or a collar if you are concerned. Later in the fall I noticed some leg tremors when she squatted. He is also running a fever so is not out of the woods. I couldnt figure it out until I googled all the medications the vet has prescribed for her then I came across this forum and I am pissed!! This can help with feelings of anxiety, stress, and fear." She has been on it for 6 months. By the following day, she was showing symptoms of marked neurological impairment, similar to a human having suffered a stroke. I called the breeder, and she said some vaccines and heartworm meds can cause neurological issues. If she continues I will be going to the vet. Come to find out Akita blood platelets can explode in storage causing hi readings. Even when asked to go for a car ride he didn't respond. No this puppy hasnt had seizures and I came to this forum to see other problems with this medicine. I was reading that this drug enters the bloodstream quickly after giving it, and these symptoms and all the other reports have convinced me that I'm done using this on my pup. We started the medication on Dec. 1st and 3 days later it started with vomiting and loss of appetite. Im done with this drug! How do I get this out of his system and what are you using instead? A week ago I gave him Trifexis because he had been on it a few years ago.the next night he had a seizure. Get practical pet health tips, articles, and insights from our veterinary community delivered weekly to your inbox. I brought him to the vet and they keep trying to say excessive water drinking isnt a side effect but its the only thing that is different that Ive given my pup. I've had to syringe water in his mouth. To make dosing easy, it's available for dogs in six sizes based on body weight range: Simparica Trio can be given to dogs with or without food. He cant handle those unexpected noises. We have given him pedialyte. Random vomitting is no fun either. I thought maybe he got into something. Although vet wanted to treat him for Addison's I decided to wait it out and fortunately it worked out. He is very whinny and is drinking a lot of water. He was diagnosed with "Sundowners" . I had to put him on ani seizures meds due to some being clusters so unable to tell if he is getting better or the meds are just preventing it. Hey carol im so sorry to hear about your dog? My 5 year old Fox Hound isnow drinking lots of water and urinating in the house! Vets have told us repeatedly that it can't be the medication. He has never done this, and when I heard it and woke up he couldn't stop. 24 hours after, we noticed diarrhea. Her poor top underside of her tail has raw skin the hair is completely gone like burnt off from diarrhea. The door is open , its where he prefers to sleep on a doggie bed . I won't sleep until we all get the justice for our babies that don't have voices of their own. But he had a terrifying seizure when I was out walking him on December 26, 2020 with no previous known history (he is rescue I've had since he was 2). Gave our 23 month old Black Lab. He did blood work and found that the phosphorus levels in her blood were way to low and that was causing the neurogical problems and it was most likely from Simparica Trio. Find the Right Simparica for your dog. I used to use revolution but they dont cover ticks as well. There is also a chance that hell need a surgery. My last one lived to almost 15yrs old and I truly believe it was because I had him on Springtime Garlic tabs. Then a week later 2 more just 24 hours apart then a little over w week later she had 3 in 24 hours. In total we spend around $780 trying to control/stop the tremors & seizures. Another possibility would be that the dosage was to high for her (simparica comes in three different dosages). I got my dog Josey up to let him out to pee. I did some research and because he seemed otherwise fine, I assumed it was "small white dog" shaking due to his breed mix. These are: Twitching and muscle tremors. I thought it was them not liking the food and made a change. This should be taken off the market-it's just a BIG pharmaceutical moneymaker at the expense of animals and their unsuspecting owners. It really helped us to put this diarrhea condition in perspective. My 2 year old Shepherd was perfectly healthy in Feb. and by April of this year he quit eating, excessive thirst, excessive urination, low platelet count, low red blood cell count is unsteady and now is at a vet hospital and so far we have spent 2000 and they do not know what is wrong with him. But I have heard of other dogs who recover, or who continue having seizures but not fatal. Kristine, unfortunately my sweet Dolly passed away on October 9th. Yep days ago started vomiting and having seizures. After realizing that the only thing that we did differently was to give him his first dose of Simperica, my wife began research and came across this conversation. That was when I lived in Fort Lauderdale. I thought the first one it happened to may have gotten something in her eye but then a few days later the other had the same issue. after a few months of this i decided to go back to Sentinel and Bravecto. This happened the same to my dog.. how si going now with your pet? We all want to protect our pets from fleas, ticks and the diseases they carry, but some treatments can come with nasty side effects. We gave our 13 yr old lab mix this medicine as our doctor doesn't carry trifexis anymore. Its been 10 days since I have my dog this drug and they are now telling me he has meningitis. I left a lot out but didnt want to make too lengthy post. Especially after seeing these post. That trip cost $400 and the result was he needed Simparica flea treatment. Hoping you are the lucky ones!! Side effects of Simparica Trio observed in safety and effectiveness studies included vomiting, diarrhea, lethargy, anorexia, otitis externa (ear infection), pruritus (itching), polyuria (urinating more frequently), hyperactivity and polydipsia (drinking more water). As of today, Sadie's ability to eventually meet the strict certification requirements in that pursuit, remains guarded, although her progress prior to this event had been stellar. I have an appointment this Wednesday but not sure if Im going to keep it if the cough will go away eventually. We gave our one year old Simparica tonight and he started having trimmers that lasted on and off for about 30 minutes. If undiagnosed he would have died. How common are Simparica side effects? I am hopeful he will make it through the next few weeks. Simparica Trio chewable tablets for dogs 44-88 lbs For Instance he has never liked grooming, I brushed him out last night and he slept through the whole thing. In other words, they can make it easier to have a seizure in susceptible dogs. The only thought in my head was to get home and give it to my puppy who has had few fleas, but many itching problems. I gave them their 2nd dose, and 24 hours later, the Collie mix (Bella) was throwing up, lethargic, unsteady, drinking obsessively, panting, and could hardly walk. We gave our guy one dose about a week ago and same day he had had a seizure. 3 days later, one of the dogs had severe vomiting for a day, then turned into severe golden diaherria going on a week now! My dog has had 3 seizures in the past from wearing a flea collar. Although the mother that took the same had not shown any effects. 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