A really multi-functional helper ingredient that can do several things in a skincare product: it can bring a soft and pleasant feel to the formula, it can act as a humectant and emollient, it can be a solvent for some other ingredients (for example it can help to stabilize perfumes in watery products) and it can also help to disperse pigments Hu, J. View abstract. Hao, H., Aixia, Y., Dan, L., Lei, F., Nancai, Y., and Wen, S. Baicalin suppresses expression of Chlamydia protease-like activity factor in Hep-2 cells infected by Chlamydia trachomatis. Taking large amounts of Baikal skullcap along with alcohol might cause too much sleepiness. View abstract. Phytother.Res 2009;23(10):1415-1420. View abstract. You, C. L., Su, P. Q., and Zhou, X. X. Chen, H. H., Hong, H. J., Chou, Y. H., Cheng, T. H., Chen, J. J., and Lin, H. Inhibition of cyclic strain-induced endothelin-1 secretion by baicalein in human umbilical vein endothelial cells. Bull Exp Biol Med 2002;134(1):47-49. Case ReportsAcute liver injury: In patients with arthritis, following consumption of formulas containing baicalin derived from S. baicalensis or Chinese skullcap(18)(24). Guang.Pu.Xue.Yu Guang.Pu.Fen.Xi. Quality evaluation of commercial extracts of Scutellaria baicalensis. Am J Chin Med 2006;34(2):245-261. Different effects of baicalein, baicalin, and wogonin on mitochondrial function, glutathione content and cell cycle progression in human hepatoma cell lines. View abstract. The ethanol extract of Scutellaria baicalensis and the active compounds induce cell cycle arrest and apoptosis including upregulation of p53 and Bax in human lung cancer cells. Biomed.Chromatogr. J Biomed.Sci 2009;16:27. WebIt also contains chemicals that might have anti-inflammatory and antioxidant effects. Yune, T. Y., Lee, J. Y., Cui, C. M., Kim, H. C., and Oh, T. H. Neuroprotective effect of Scutellaria baicalensis on spinal cord injury in rats. Chromatographic fingerprint and quantitative analysis of seven bioactive compounds of, Inhibition of Tumor Growth and Immunomodulatory Effects of Flavonoids and Scutebarbatines of, Using the gene expression signature of scutebarbalactone VN isolated from. Next to red peppers, you can get the most vitamin C from ________________. View abstract. Tarrago, T., Kichik, N., Claasen, B., Prades, R., Teixido, M., and Giralt, E. Baicalin, a prodrug able to reach the CNS, is a prolyl oligopeptidase inhibitor. Pharmacol.Res. J Ethnopharmacol. Allergic contact dermatitis to Tinosorb S, Scutellaria baicalensis, and other emerging allergens in cosmetics. Baicalin is believed to interfere with hormonal reactions and release of histamines and bile in the body; it stimulates gallbladder activity, inhibits inflammation, as well as suppresses the activity of leukaemia-derived T-cells and replication of viruses and bacteria. Eksp.Klin Farmakol. Anticonvulsant effect of wogonin isolated from. View abstract. View abstract. Chou TC, Chang LP, Li CY, et al. If you have any condition that might be made worse by exposure to estrogen, don't use Baikal. View abstract. Yotsumoto, H., Yanagita, T., Yamamoto, K., Ogawa, Y., Cha, J. Y., and Mori, Y. Inhibitory effects of oren-gedoku-to and its components on cholesteryl ester synthesis in cultured human hepatocyte HepG2 cells: evidence from the cultured HepG2 cells and in vitro assay of ACAT. J Ethnopharmacol. Letter/Prescriber's Letter. Broncel, M. [Antiatherosclerotic properties of flavones from the roots of Scutellaria baicalensis Georgi]. Diabetes: Baikal skullcap can affect blood sugar levels in people with diabetes. Different extracts of this herb have been found to kill cancer cells in the body, but human research is pending in this field. Baikal skullcap might lower blood sugar levels. From: Polyphenols in Human Health and Disease, 2014. A large long-term population study identifies S. barbata among the single herbs used in TCM that may reduce risk of hepatocellular carcinoma in hepatitis B patients(9). Mu, X., He, G., Cheng, Y., Li, X., Xu, B., and Du, G. Baicalein exerts neuroprotective effects in 6-hydroxydopamine-induced experimental parkinsonism in vivo and in vitro. Front Biosci. View abstract. A sugar beet-derived amino acid derivative with nice skin protection and moisturization properties.Betaine's special thing is being an osmolyte, a molecule that helps to control cell-water balance.It is also a natural osmoprotectant, meaning that it attracts water away from the protein surface and thus protects them from denaturation and WebSide Effects Precautions Interactions Dosing Reviews (4) Overview Baikal skullcap (Scutellaria baicalensis) is a plant native to China and Korea. Studies on inhibitors of skin tumor promotion. With cancer, where you get treated first matters. Baikal skullcap is POSSIBLY SAFE for most adults when taken by mouth. However, there are concerns that this combination product might cause liver problems in some people. View abstract. Neurosci Lett. Jianjun, J. and Huiru, D. Preparation of high-purity baicalein from Scutellaria baicalensis Georgi. View abstract. WebThe root of Scutellaria baicalensis is used as medicine. The effect of he jie decoction on the TCRV beta 7 of chronic hepatitis B patients. 11-1-2009;284(2):198-207. September 2012. Int Immunopharmacol. Efficacy and safety of flavocoxid, a novel therapeutic, compared with naproxen: a randomized multicenter controlled trial in subjects with osteoarthritis of the knee. Vopr.Onkol. Liu, J. J., Huang, T. S., Cheng, W. F., and Lu, F. J. Baicalein and baicalin are potent inhibitors of angiogenesis: Inhibition of endothelial cell proliferation, migration and differentiation. Preliminary study of traditional Chinese medicine treatment of minimal brain dysfunction: analysis of 100 cases. Kumagai, T., Muller, C. I., Desmond, J. C., Imai, Y., Heber, D., and Koeffler, H. P. Scutellaria baicalensis, a herbal medicine: anti-proliferative and apoptotic activity against acute lymphocytic leukemia, lymphoma and myeloma cell lines. Shih, H. C., Hsu, C. S., and Yang, L. L. In vitro study of the tocolytic effect of oroxylin A from Scutellaria baicalensis root. Chinese Journal of Gerontology 2010;30(7):926-928. ]. Lin H, Zhou J, Lin K, et al. Yuan Y., Liu Y.J, Luo Y.J, and et al. Whether co-administration of garlic has negative influence on Scutellaria baicalensis Georgi in treating models rats with pelvic inflammation? The effects of acute and repeated oroxylin A treatments on Abeta(25-35)-induced memory impairment in mice. WebScutellaria baicalensis, a medicinal herb belonging to the Lamiaceae family, has been recorded in the Chinese, European, and British Pharmacopoeias. Taking Baikal skullcap along with diabetes medications might cause your blood sugar to go too low. Acta Pharmacol Sin. View abstract. View abstract. Baikal skullcap is used to treat respiratory infections, hay fever, and fever. There are no known side effects of using scutellaria baicalensis root extract and it is considered gentle enough for sensitive skin types to use. J Ethnopharmacol. Z. View abstract. Afr J Tradit Complement Altern Med. Kaplya, O. Chalasani N, Vuppalanchi R, Navarro V, et al. Wang R.T, Zhang J.X, and Dong Y.J. Zhongguo Zhong.Yao Za Zhi 2010;35(6):682-685. Zhou, J., Qu, F., Burrows, E., Yu, Y., and Nan, R. Acupuncture can improve absorption of baicalin from extracts of Scutellaria baicalensis Georgi in rats. Drugs 2005;65(9):1239-1282. Z., Bai, L., Chen, D. G., Xu, Q. T., and Southerland, W. M. Computational investigation of the anti-HIV activity of Chinese medicinal formula Three-Huang Powder. Chang, Y. L., Shen, J. J., Wung, B. S., Cheng, J. J., and Wang, D. L. Chinese herbal remedy wogonin inhibits monocyte chemotactic protein-1 gene expression in human endothelial cells. Mol Pharmacol 2001;60(3):507-513. Takeshita K, Saisho Y, Kitamura K, et al. View abstract. View abstract. 2002;51(6):277-283. View abstract. 2nd ed. Naunyn-Schmiedeberg Arch Pharmacol 2006;372:432-43. Udintsev, S. N., Razina, T. G., and Iaremenko, K. V. [The antitumor effect of Baikal skullcap]. However, both S. baicalensis root and its main flavonoid baicalin appear to have dose-dependent pro- and anti-angiogenic effects(9). Lixuan, Z., Jingcheng, D., Wenqin, Y., Jianhua, H., Baojun, L., and Xiaotao, F. Baicalin attenuates inflammation by inhibiting NF-kappaB activation in cigarette smoke induced inflammatory models. African Journal of Biotechnology 2011;10(26):5182-5192. 5-24-2006;105(3):346-351. Chang, W. H., Chen, C. H., and Lu, F. J. Li BQ, Fu T, Gong WH, et al. A., Lee, K., Hwangbo, H., Park, E., Kim, M., and Ma, W. Detection of the potential adulterant Teucrium chamaedrys in Scutellaria baicalensis raw material and extract by high-performance thin-layer chromatography. View abstract. View abstract. View abstract. There have been reports of fever and lung inflammation in people who took Baikal skullcap. Huang, Y., Tsang, S. Y., Yao, X., and Chen, Z. Y. Nutr Cancer 2004;49(2):217-22. Ye, F., Wu, J., Dunn, T., Yi, J., Tong, X., and Zhang, D. Inhibition of cyclooxygenase-2 activity in head and neck cancer cells by genistein. Major issues are not reported regarding the result of this Chinese herb, but it is mandatory to take some of the mandatory precautions. Planta Med 1997;63(2):141-145. Contact Dermatitis. View abstract. Zhong.Yao Cai. J Dent Res 1982;61(9):1103-1106. Nontoxic; LD 50 is tested, none. View abstract. View abstract. J Nat Prod 2009;72(9):1616-1619. View abstract. 1990;36(5):602-607. Low blood pressure: Baikal skullcap might lower blood pressure. Yao Xue.Xue.Bao. WebDescription:scutellaria baicalensis root extract is an extract of the roots of the scutellaria baicalensis, lamiaceae. Different apoptotic effects of wogonin via induction of H(2)O(2) generation and Ca(2+) overload in malignant hepatoma and normal hepatic cells. Ye, F., Wu, J., Dunn, T., Yi, J., Tong, X., and Zhang, D. Inhibition of cyclooxygenase-2 activity in head and neck cancer cells by genistein. Curr Neurol.Neurosci.Rep. Stop using Baikal skullcap at least 2 weeks before a scheduled surgery. Zhou, J., Qu, F., Zhang, H. J., Zhuge, X. H., and Cheng, L. Z. This will help them manage your care and keep you safe. View abstract. baicalensis, also known as Huang Qin or Chinese skullcap, is a root extract used in traditional medicine. If you are on any medication such as warfarin or any other blood-thinning medicine, then it is advised to stay away from the herb. Some people use Baikal skullcap for HIV/AIDS, kidney infections, pelvic inflammation, and sores or swelling. Ceska.Slov.Farm. Baikal skullcap can also affect most peoples blood sugar levels, but people with diabetes can get negative results with the herb. Li L, Gao H, Lou K, et al. Some of the supplements and medicines containing Scutellaria baicalensis herb have been shown to reduce the symptoms of arthritis and joint pain. 2-1-2010;84(2):137-144. 2020 May;82(5):307-309. Many lab tests have shown that this time is a herb that also results in blood thinning which can cause an increased risk of bleeding and bruising. Wang R.T, Zhang J.X, and Dong Y.J. Shieh, D. E., Cheng, H. Y., Yen, M. H., Chiang, L. C., and Lin, C. C. Baicalin-induced apoptosis is mediated by Bcl-2-dependent, but not p53-dependent, pathway in human leukemia cell lines. This Web site Information About Herbs, Botanicals and Other Products is for general health information only. 4-1-2011;492(2):76-79. A Medicinal Plant Extract of Scutellaria Baicalensis and Acacia Catechu Reduced LPS-Stimulated Gene Expression in Immune Cells: A Comprehensive Genomic Study Using QPCR, ELISA, and Microarray. Ju, W. Z., Liu, F., Wu, T., Xia, X. Y., Tan, H. S., Wang, X., and Xiong, N. N. [Simultaneous determination of baicalin and chlorogenic acid in human plasma by UPLC-MS/MS]. 2010;36(3):329-338. A., Attele, A. S., Zhang, L., and Yuan, C. S. Anti-HIV activity of medicinal herbs: usage and potential development. Opposite expression of securin and gamma-H2AX regulates baicalein-induced cancer cell death. If you take it, consider monitoring your blood sugar level regularly and pay proper attention to the amount of Baikal skullcap. Pharmacotherapy 2010;30(7):750, 258e-750, 262e. Kim, E. H., Shim, B., Kang, S., Jeong, G., Lee, J. S., Yu, Y. From diagnosis to treatment, our experts provide the care and support you need, when you need it. Jeong, K., Shin, Y. C., Park, S., Park, J. S., Kim, N., Um, J. Y., Go, H., Sun, S., Lee, S., Park, W., Choi, Y., Song, Y., Kim, G., Jeon, C., Park, J., Lee, K., Bang, O., and Ko, S. G. Ethanol extract of Scutellaria baicalensis Georgi prevents oxidative damage and neuroinflammation and memorial impairments in artificial senescense mice. View abstract. WebAntiinflammatory effects of baicalin have been shown in HK-2 cells cultured in a diabetic milieu consisting of high glucose, advanced glycation end products, and TNF, in which it reduces NF-B and JAKSTAT signaling [176]. Certain flavonoid components appear to have anticancer activity in vitro: wogonin caused G1 arrest, while baicalin and baicalein cause G2/M accumulation(2). The root has been used in Chinese medicine for psychiatric disorders. Yoon, S. B., Lee, Y. J., Park, S. K., Kim, H. C., Bae, H., Kim, H. M., Ko, S. G., Choi, H. Y., Oh, M. S., and Park, W. Anti-inflammatory effects of Scutellaria baicalensis water extract on LPS-activated RAW 264.7 macrophages. 11-28-2000;160(2):219-228. View abstract. Regulska-Ilow, B., Biernat, J., Grajeta, H., Ilow, R., and Drzewicka, M. Influence of bioflavonoids from the radix extract of Scutellaria baicalensis on the level of serum lipids, and the development of laboratory rats fed with fresh and oxidized fats. But there isn't enough information to know if this is an important interaction. J Med Food 2014;17(6):707-13. Shim K.S, Kim S.N, Kim M.H, and et al. [Application of XRF to the analysis of Scutellaria baicalensis with space mutagenesis]. Pasanen MK, Fredrikson H, Neuvonen PJ, Niemi M. Different effects of SLCO1B1 polymorphism on the pharmacokinetics of atorvastatin and rosuvastatin. Baikal skullcap might have some of the same effects as estrogen. You may ask and answer a query. Ye F, Wang H, Jiang S, et al. 12-10-2008;8(12):1652-1657. View abstract. Konig J, Seithel A, Gradhand U, Fromm MF. 10-18-2009;41(5):578-584. Pursuing basic and translational research across 9 programs and 100+ labs, Focusing on clinical cancer research and population health, Bridging the lab and the clinic through translational research, Fostering interdisciplinary collaborations between laboratory scientists and clinicians, Partnering with other academic and research institutions, Offering state-of-the-art resources for our researchers, Offering a curriculum with a focus on cancer, Connecting college seniors to future careers in biomedicine, 2023 Memorial Sloan Kettering Cancer Center, Human Oncology & Pathogenesis Program (HOPP), Gerstner Sloan Kettering Graduate School of Biomedical Sciences, High school & undergraduate summer programs, Integrative Medicine at Home Membership Program, Characterization of chemical constituents in. View abstract. Jin BR, Chung KS, Kim HJ, An HJ. Guo, H. X., Liu, D. H., Ma, Y., Liu, J. F., Wang, Y., Du, Z. Y., Wang, X., Shen, J. K., and Peng, H. L. Long-term baicalin administration ameliorates metabolic disorders and hepatic steatosis in rats given a high-fat diet. Efficacy of Scutellaria baicalensis for the treatment of hand, foot, and mouth disease associated with encephalitis in patients infected with EV71: a multicenter, retrospective analysis. Herbal hepatoxicity from Chinese skullcap: A case report. Vopr.Onkol. Differential interaction of 3-hydroxy-3-methylglutaryl-CoA reductase inhibitors with ABCB1, ABCC2, and OATP1B1. Huang, R. L., Chen, C. C., Huang, H. L., Chang, C. G., Chen, C. F., Chang, C., and Hsieh, M. T. Anti-hepatitis B virus effects of wogonin isolated from Scutellaria baicalensis. Zhang H and Huang J. Pulm.Pharmacol Ther 2010;23(5):411-419. Most of the studies related to Scutellaria baicalensis are done in the laboratory and not on real humans. Baikal skullcap might slow blood clotting. However, it is not known if the herb would exert similar effects by itself, and cases of hepatotoxicity with some supplements have been reported(18)(24). Chan, E., Liu, X. X., Guo, D. J., Kwan, Y. W., Leung, G. P., Lee, S. M., and Chan, S. W. Extract of Scutellaria baicalensis Georgi root exerts protection against myocardial ischemia-reperfusion injury in rats. The antiinflammatory and analgesic effects of baicalin in carrageenan-evoked thermal hyperalgesia. View abstract. View abstract. Morgan SL, Baggott JE, Moreland L, et al. Contact Dermatitis 2022. Planta Med 2010;76(7):678-682. Baikal skullcap is also sometimes applied to the skin for psoriasis. View abstract. This could increase how much lithium is in the body and result in serious side effects. Planta Med 2011;77(5):455-460. Studies indicate that aqueous extracts suppressed the growth of lymphoma and myeloma cells. 7-28-2004;211(1):39-46. Natural Product Sciences 2008;14(3):182-186. Biological properties of baicalein in cardiovascular system. Liu, J. J., Huang, T. S., Cheng, W. F., and Lu, F. J. Baicalein and baicalin are potent inhibitors of angiogenesis: Inhibition of endothelial cell proliferation, migration and differentiation. WebBaicalin is a great herbal supplement for health benefits. Interdiscip.Sci 2010;2(2):151-156. View abstract. 4 Physical and Chemicals Properties Scutellaria Baicalensis Root Extract In an ultraviolet (UV) spectral analysis of a Scutellaria baicalensis root extract (aqueous ethanol extract), an absorption peak between 200 and 250 nm and an absorption peak between 250 and 300 nm were Some medications are changed and broken down by the liver. BMC.Complement Altern Med 2006;6:27. Altern.Ther.Health Med. View abstract. Monitor your blood sugar closely. View abstract. View abstract. Scutellaria baicalensis root: Uses, Interactions, Mechanism of Action | DrugBank Online Cancer Res 7-15-2003;63(14):4037-4043. Scutellaria baicalensis is a Chinese root extract used in several traditional medicines to treat different problems. View abstract. Wang, J., Yu, Y., Hashimoto, F., Sakata, Y., Fujii, M., and Hou, D. X. Baicalein induces apoptosis through ROS-mediated mitochondrial dysfunction pathway in HL-60 cells. J Biomed.Sci 2009;16:27. Integr.Cancer Ther. Chinese skullcap can decrease the blood level of several drugs used to lower cholesterol levels. Difference of growth-inhibitory effect of Scutellaria baicalensis-producing flavonoid wogonin among human cancer cells and normal diploid cell. The root is used to make medicine. View abstract. View abstract. 1999;385-6, 400-1. View abstract. Blood 2-15-2008;111(4):2354-2363. A traditional Chinese herbal medicine loaded with potent antioxidant and anti-inflammatoryflavonoids such as baicalin, baicalein, and wogonin. [Study on effect and mechanism of scutellaria baicalensis stem-leaf total flavonoid in regulating lipid metabolism]. Ann N Y Acad Sci 2007;1095:521-526. View abstract. Jiang, R. H., Su, W. C., Liu, H. F., Huang, H. S., and Chao, J. I. In this article, we explore the top Baicalin benefits that you can experience today. The ethyl acetate (EtOAc) extract showed high ROS scavenging ability, and four compounds were subsequently isolated and purified from this extract: baicalin, View abstract. Lee, B. S., Shim, S. M., Heo, J., Pae, H. O., Seo, B. Y., Han, S. Y., Sohn, D. H., Jang, S. I., and Chung, H. T. Wogonin suppresses TARC expression induced by mite antigen via heme oxygenase 1 in human keratinocytes. How It Works Purported Uses and Benefits Do Not Take If Side Effects Special Point Back to top For Flavocoxid, a dual inhibitor of cyclooxygenase and 5-lipoxygenase, blunts pro-inflammatory phenotype activation in endotoxin-stimulated macrophages. numbuzin No.3 Porcelain Base-skip Tone Up Beige ingredients explained: Water, Zinc Oxide, Cyclohexasiloxane, Propanediol, Propylheptyl Caprylate, Caprylyl Methicone, Trimethylsiloxysilicate, Polyglyceryl-3 Polydimethylsiloxyethyl Dimethicone, Titanium Dioxide, Niacinamide, Disiloxane, Butyloctyl Salicylate, Centella Asiatica View abstract. Zhang H, Huang J. Adam T, Bursztejn AC, Schmutz JL. Tell your healthcare providers about any dietary supplements youre taking, such as herbs, vitamins, minerals, and natural or home remedies. Dose Dependent Dual Effect of Baicalin and Herb Huang Qin Extract on Angiogenesis. Papafragkakis C, Ona MA, Reddy M, Anand S. Acute hepatitis after ingestion of a preparation of Chinese skullcap and black catechu for joint pain. Some medications are changed and broken down by the liver. Do you know this herb by any other name ? The flavonoid baicalin exhibits anti-inflammatory activity by binding to chemokines. Flavocoxid is as effective as naproxen for managing the signs and symptoms of osteoarthritis of the knee in humans: a short-term randomized, double-blind pilot study. This beneficial medicinal herb has many uses to treat different diseases and health conditions. Acute liver injury due to flavocoxid (Limbrel), a medical food for osteoarthritis: a case series. View abstract. In Vivo 2004;18(4):497-503. Baikal skullcap might also lower blood sugar. View abstract. View abstract. A proprietary aqueous S. barbata extract appears to target tumor mitochondria to induce ROS generation and DNA damage followed by PARP hyperactivation, cellular ATP and NAD depletion, and glycolysis inhibition(33). This is especially relevant to macrophages and immune cells. Wu X, Zhang H, Salmani JM, et al. Scutellaria baicalensis extract containing baicalin (a flavone, type of flavonoid, is a major bioactive compound) has been used in traditional Facial eczema from a sunscreen: Scutellaria baicalensis, a novel allergen beginning to attract attention. See additional information. 1-29-2010;469(3):298-302. You, J., Gao, S., Jin, H., Li, W., Zhang, H., and Yu, A. On-line continuous flow ultrasonic extraction coupled with high performance liquid chromatographic separation for determination of the flavonoids from root of Scutellaria baicalensis Georgi. View abstract. View abstract. 2009;29(2):519-521. Li, B. Q., Fu, T., Dongyan, Y., Mikovits, J. 5. View abstract. View abstract. The appropriate dose of Baikal skullcap depends on several factors such as the user's age, health, and several other conditions. Lee, C. Y., Wang, J. Y., Chen, T. C., Jiang, J. K., Peng, C. H., Kuo, C. D., Chang, W. C., Chiu, J. H., and Wu, C. W. Effects of S/B remedy containing Scutellaria baicalensis and Bupleurum scorzonerifolfium on hepatic interleukin-6 related signal transducer and activator of transcription 3 activation in mice through cell-cell interaction. Least 2 weeks before a scheduled surgery levels, but it is mandatory to take some of the effects... Next to red peppers, you can get the most vitamin C ________________! Binding to chemokines R.T, Zhang, H. J., Qu, F. Zhang... Is a great herbal supplement for health benefits treating models rats with pelvic inflammation, Mikovits,.. Treating models rats with pelvic inflammation H, Huang J. Adam T, Bursztejn AC, Schmutz JL Zhou! Difference of growth-inhibitory effect of Baikal skullcap to Scutellaria baicalensis root extract in. Xrf to the amount of Baikal skullcap along with diabetes also contains chemicals that might have some of roots! Lithium is in the Chinese, European, and sores or swelling N.. 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